| 2021-10-17 11:00:0017/10/21 | 1928 Vetralla — Fortitudo Nepi Calcio | 0 - 0 | Raparelli Goffredo |
| 2021-10-17 11:00:0017/10/21 | Castel S.Elia L.Graziosi — Cura Calcio | 0 - 0 | Darida Michele |
| 2021-10-17 11:00:0017/10/21 | Atletico Cimina — Sporting Bagnoregio | 2 - 1 | Palozzi Rosato |
| 2021-10-17 11:00:0017/10/21 | Atletico Capranica — Maremmana 1934 | 1 - 2 | Morera Manlio |
| 2021-10-17 15:00:0017/10/21 | S.Lorenzo N. — Valentano | 0 - 1 | Comunale |
| 2021-10-17 15:30:0017/10/21 | Vicus Ronciglione — Allumiere | 4 - 2 | Ginnasi Valerio |
| 2021-10-17 15:30:0017/10/21 | Tarquinia Calcio — G.B. Bagnaia | 2 - 0 | Bonelli Liviano |
| 2021-10-24 11:00:0024/10/21 | Valentano — Atletico Capranica | 1 - 1 | Felceti |
| 2021-10-24 11:00:0024/10/21 | Sporting Bagnoregio — Castel S.Elia L.Graziosi | 0 - 2 | Pompei Alessandro |
| 2021-10-24 11:00:0024/10/21 | G.B. Bagnaia — Vicus Ronciglione | 0 - 1 | Buratti-Burocchi |
| 2021-10-24 11:00:0024/10/21 | Fortitudo Nepi Calcio — S.Lorenzo N. | 1 - 2 | Comunale |
| 2021-10-24 11:00:0024/10/21 | Cura Calcio — 1928 Vetralla | 4 - 1 | Nagni Luigi |
| 2021-10-24 15:30:0024/10/21 | Maremmana 1934 — Tarquinia Calcio | 0 - 1 | Incotti |
| 2021-10-24 15:30:0024/10/21 | Allumiere — Atletico Cimina | 2 - 0 | La Cavaccia |
| 2021-10-31 11:00:0031/10/21 | 1928 Vetralla — Sporting Bagnoregio | 4 - 0 | Raparelli Goffredo |
| 2021-10-31 11:00:0031/10/21 | Castel S.Elia L.Graziosi — Allumiere | 1 - 0 | Darida Michele |
| 2021-10-31 11:00:0031/10/21 | Atletico Cimina — Vicus Ronciglione | 0 - 0 | Palozzi Rosato |
| 2021-10-31 11:00:0031/10/21 | Atletico Capranica — Fortitudo Nepi Calcio | 1 - 1 | Morera Manlio |
| 2021-10-31 14:30:0031/10/21 | Tarquinia Calcio — Valentano | 1 - 0 | Bonelli Liviano |
| 2021-10-31 14:30:0031/10/21 | Maremmana 1934 — G.B. Bagnaia | 1 - 1 | Incotti |
| 2021-10-31 15:00:0031/10/21 | S.Lorenzo N. — Cura Calcio | 0 - 0 | Comunale |
| 2021-11-07 11:00:0007/11/21 | Valentano — Maremmana 1934 | 1 - 1 | Felceti |
| 2021-11-07 11:00:0007/11/21 | Sporting Bagnoregio — S.Lorenzo N. | 0 - 3 | Pompei Alessandro |
| 2021-11-07 11:00:0007/11/21 | G.B. Bagnaia — Atletico Cimina | 2 - 1 | Buratti-Burocchi |
| 2021-11-07 11:00:0007/11/21 | Fortitudo Nepi Calcio — Tarquinia Calcio | 0 - 1 | Comunale |
| 2021-11-07 11:00:0007/11/21 | Cura Calcio — Atletico Capranica | 3 - 0 | Nagni Luigi |
| 2021-11-07 14:30:0007/11/21 | Vicus Ronciglione — Castel S.Elia L.Graziosi | 2 - 0 | Ginnasi Valerio |
| 2021-11-07 14:30:0007/11/21 | Allumiere — 1928 Vetralla | 2 - 1 | La Cavaccia |
| 2021-11-14 11:00:0014/11/21 | 1928 Vetralla — Vicus Ronciglione | 1 - 0 | Raparelli Goffredo |
| 2021-11-14 11:00:0014/11/21 | Valentano — G.B. Bagnaia | 5 - 0 | Felceti |
| 2021-11-14 11:00:0014/11/21 | Castel S.Elia L.Graziosi — Atletico Cimina | 3 - 3 | Darida Michele |
| 2021-11-14 11:00:0014/11/21 | Atletico Capranica — Sporting Bagnoregio | 7 - 1 | Morera Manlio |
| 2021-11-14 14:30:0014/11/21 | Tarquinia Calcio — Cura Calcio | 3 - 1 | Bonelli Liviano |
| 2021-11-14 14:30:0014/11/21 | Maremmana 1934 — Fortitudo Nepi Calcio | 1 - 0 | Incotti |
| 2021-11-14 15:00:0014/11/21 | S.Lorenzo N. — Allumiere | 1 - 0 | Comunale |
| 2021-11-21 11:00:0021/11/21 | Sporting Bagnoregio — Tarquinia Calcio | 1 - 3 | Pompei Alessandro |
| 2021-11-21 11:00:0021/11/21 | G.B. Bagnaia — Castel S.Elia L.Graziosi | 1 - 2 | Buratti-Burocchi |
| 2021-11-21 11:00:0021/11/21 | Fortitudo Nepi Calcio — Valentano | 3 - 1 | Comunale |
| 2021-11-21 11:00:0021/11/21 | Cura Calcio — Maremmana 1934 | 1 - 1 | Nagni Luigi |
| 2021-11-21 11:00:0021/11/21 | Atletico Cimina — 1928 Vetralla | 0 - 0 | Palozzi Rosato |
| 2021-11-21 14:30:0021/11/21 | Vicus Ronciglione — S.Lorenzo N. | 0 - 1 | Ginnasi Valerio |
| 2021-11-21 14:30:0021/11/21 | Allumiere — Atletico Capranica | 0 - 1 | La Cavaccia |
| 2021-11-28 11:00:0028/11/21 | 1928 Vetralla — Castel S.Elia L.Graziosi | 0 - 0 | Raparelli Goffredo |
| 2021-11-28 11:00:0028/11/21 | Valentano — Cura Calcio | 1 - 0 | Felceti |
| 2021-11-28 11:00:0028/11/21 | Fortitudo Nepi Calcio — G.B. Bagnaia | 3 - 1 | Comunale |
| 2021-11-28 11:00:0028/11/21 | Atletico Capranica — Vicus Ronciglione | 5 - 1 | Morera Manlio |
| 2021-11-28 14:30:0028/11/21 | Tarquinia Calcio — Allumiere | 1 - 1 | Bonelli Liviano |
| 2021-11-28 14:30:0028/11/21 | Maremmana 1934 — Sporting Bagnoregio | 3 - 1 | Incotti |
| 2021-11-28 15:00:0028/11/21 | S.Lorenzo N. — Atletico Cimina | 1 - 2 | Comunale |
| 2021-12-05 11:00:0005/12/21 | Sporting Bagnoregio — Valentano | 0 - 2 | Pompei Alessandro |
| 2021-12-05 11:00:0005/12/21 | G.B. Bagnaia — 1928 Vetralla | 3 - 3 | Buratti-Burocchi |
| 2021-12-05 11:00:0005/12/21 | Cura Calcio — Fortitudo Nepi Calcio | 1 - 0 | Nagni Luigi |
| 2021-12-05 11:00:0005/12/21 | Castel S.Elia L.Graziosi — S.Lorenzo N. | 1 - 1 | Darida Michele |
| 2021-12-05 11:00:0005/12/21 | Atletico Cimina — Atletico Capranica | 2 - 1 | Palozzi Rosato |
| 2021-12-05 14:30:0005/12/21 | Vicus Ronciglione — Tarquinia Calcio | 1 - 1 | Ginnasi Valerio |
| 2021-12-05 14:30:0005/12/21 | Allumiere — Maremmana 1934 | 2 - 0 | La Cavaccia |
| 2021-12-12 11:00:0012/12/21 | Valentano — Allumiere | 3 - 2 | Felceti |
| 2021-12-12 11:00:0012/12/21 | Fortitudo Nepi Calcio — Sporting Bagnoregio | 3 - 0 | Comunale |
| 2021-12-12 11:00:0012/12/21 | Cura Calcio — G.B. Bagnaia | 3 - 1 | Nagni Luigi |
| 2021-12-12 11:00:0012/12/21 | Atletico Capranica — Castel S.Elia L.Graziosi | 1 - 0 | Morera Manlio |
| 2021-12-12 14:30:0012/12/21 | Tarquinia Calcio — Atletico Cimina | 1 - 0 | Bonelli Liviano |
| 2021-12-12 14:30:0012/12/21 | Maremmana 1934 — Vicus Ronciglione | 1 - 1 | Incotti |
| 2021-12-12 15:00:0012/12/21 | S.Lorenzo N. — 1928 Vetralla | 3 - 3 | Comunale |
| 2021-12-19 11:00:0019/12/21 | 1928 Vetralla — Atletico Capranica | 1 - 2 | Raparelli Goffredo |
| 2021-12-19 11:00:0019/12/21 | Sporting Bagnoregio — Cura Calcio | 1 - 2 | Pompei Alessandro |
| 2021-12-19 11:00:0019/12/21 | G.B. Bagnaia — S.Lorenzo N. | 0 - 1 | Buratti-Burocchi |
| 2021-12-19 11:00:0019/12/21 | Castel S.Elia L.Graziosi — Tarquinia Calcio | 0 - 0 | Darida Michele |
| 2021-12-19 11:00:0019/12/21 | Atletico Cimina — Maremmana 1934 | 1 - 0 | Palozzi Rosato |
| 2021-12-19 14:30:0019/12/21 | Vicus Ronciglione — Valentano | 2 - 2 | Ginnasi Valerio |
| 2021-12-19 14:30:0019/12/21 | Allumiere — Fortitudo Nepi Calcio | 4 - 2 | La Cavaccia |
| 2022-01-09 11:00:0009/01/22 | Valentano — Atletico Cimina | 0 - 2 | Felceti |
| 2022-01-09 11:00:0009/01/22 | Sporting Bagnoregio — G.B. Bagnaia | 1 - 1 | Pompei Alessandro |
| 2022-01-09 11:00:0009/01/22 | Fortitudo Nepi Calcio — Vicus Ronciglione | 1 - 0 | Comunale |
| 2022-01-09 11:00:0009/01/22 | Cura Calcio — Allumiere | 1 - 1 | Nagni Luigi |
| 2022-01-09 11:00:0009/01/22 | Atletico Capranica — S.Lorenzo N. | 2 - 2 | Morera Manlio |
| 2022-01-09 14:30:0009/01/22 | Tarquinia Calcio — 1928 Vetralla | 2 - 1 | Bonelli Liviano |
| 2022-01-09 14:30:0009/01/22 | Maremmana 1934 — Castel S.Elia L.Graziosi | 2 - 0 | Incotti |
| 2022-02-13 11:00:0013/02/22 | Atletico Capranica — G.B. Bagnaia | 1 - 1 | Morera Manlio |
| 2022-02-13 11:00:0013/02/22 | Atletico Cimina — Fortitudo Nepi Calcio | 1 - 0 | Palozzi Rosato |
| 2022-02-13 11:00:0013/02/22 | Castel S.Elia L.Graziosi — Valentano | 1 - 0 | Darida Michele |
| 2022-02-13 11:00:0013/02/22 | 1928 Vetralla — Maremmana 1934 | 1 - 1 | San Paolo |
| 2022-02-13 14:30:0013/02/22 | S.Lorenzo N. — Tarquinia Calcio | 3 - 3 | Comunale |
| 2022-02-13 14:30:0013/02/22 | Allumiere — Sporting Bagnoregio | 2 - 1 | La Cavaccia |
| 2022-02-13 14:30:0013/02/22 | Vicus Ronciglione — Cura Calcio | 4 - 1 | Ginnasi Valerio C.Le |
| 2022-02-20 11:00:0020/02/22 | Valentano — 1928 Vetralla | 3 - 0 | Felceti |
| 2022-02-20 11:00:0020/02/22 | Sporting Bagnoregio — Vicus Ronciglione | 3 - 3 | Pompei Alessandro |
| 2022-02-20 11:00:0020/02/22 | Fortitudo Nepi Calcio — Castel S.Elia L.Graziosi | 1 - 4 | Comunale |
| 2022-02-20 11:00:0020/02/22 | Maremmana 1934 — S.Lorenzo N. | 0 - 2 | Incotti |
| 2022-02-20 11:00:0020/02/22 | Cura Calcio — Atletico Cimina | 2 - 2 | Nagni Luigi |
| 2022-02-20 11:00:0020/02/22 | G.B. Bagnaia — Allumiere | 0 - 2 | Buratti-Burocchi |
| 2022-02-20 14:30:0020/02/22 | Tarquinia Calcio — Atletico Capranica | 4 - 0 | Bonelli Liviano |
| 2022-02-27 11:00:0027/02/22 | Cura Calcio — Castel S.Elia L.Graziosi | 0 - 1 | Nagni Luigi |
| 2022-02-27 11:00:0027/02/22 | Maremmana 1934 — Atletico Capranica | 0 - 0 | Incotti |
| 2022-02-27 11:00:0027/02/22 | Fortitudo Nepi Calcio — 1928 Vetralla | 4 - 1 | Comunale |
| 2022-02-27 11:00:0027/02/22 | G.B. Bagnaia — Tarquinia Calcio | 1 - 3 | Buratti-Burocchi |
| 2022-02-27 11:00:0027/02/22 | Sporting Bagnoregio — Atletico Cimina | 1 - 0 | Pompei Alessandro |
| 2022-02-27 11:00:0027/02/22 | Valentano — S.Lorenzo N. | Rinv | Felceti |
| 2022-02-27 15:00:0027/02/22 | Allumiere — Vicus Ronciglione | 4 - 1 | La Cavaccia |
| 2022-03-06 11:00:0006/03/22 | Atletico Cimina — Allumiere | 2 - 0 | Palozzi Rosato |
| 2022-03-06 11:00:0006/03/22 | 1928 Vetralla — Cura Calcio | 0 - 0 | San Paolo |
| 2022-03-06 11:00:0006/03/22 | Castel S.Elia L.Graziosi — Sporting Bagnoregio | 8 - 0 | Darida Michele |
| 2022-03-06 11:00:0006/03/22 | Atletico Capranica — Valentano | 4 - 1 | Morera Manlio |
| 2022-03-06 15:00:0006/03/22 | S.Lorenzo N. — Fortitudo Nepi Calcio | 0 - 1 | Comunale |
| 2022-03-06 15:00:0006/03/22 | Tarquinia Calcio — Maremmana 1934 | 4 - 0 | Bonelli Liviano |
| 2022-03-06 15:00:0006/03/22 | Vicus Ronciglione — G.B. Bagnaia | 1 - 1 | Ginnasi Valerio C.Le |
| 2022-03-13 11:00:0013/03/22 | Cura Calcio — S.Lorenzo N. | 1 - 3 | Nagni Luigi |
| 2022-03-13 11:00:0013/03/22 | Fortitudo Nepi Calcio — Atletico Capranica | 2 - 1 | Comunale |
| 2022-03-13 11:00:0013/03/22 | G.B. Bagnaia — Maremmana 1934 | 3 - 2 | Buratti-Burocchi |
| 2022-03-13 11:00:0013/03/22 | Sporting Bagnoregio — 1928 Vetralla | 1 - 0 | Pompei Alessandro |
| 2022-03-13 11:00:0013/03/22 | Valentano — Tarquinia Calcio | 1 - 0 | Felceti |
| 2022-03-13 15:00:0013/03/22 | Allumiere — Castel S.Elia L.Graziosi | 1 - 0 | La Cavaccia |
| 2022-03-13 15:00:0013/03/22 | Vicus Ronciglione — Atletico Cimina | 1 - 1 | Ginnasi Valerio C.Le |
| 2022-03-20 11:00:0020/03/22 | Atletico Capranica — Cura Calcio | 1 - 0 | Morera Manlio |
| 2022-03-20 11:00:0020/03/22 | Atletico Cimina — G.B. Bagnaia | 1 - 0 | Palozzi Rosato |
| 2022-03-20 11:00:0020/03/22 | Castel S.Elia L.Graziosi — Vicus Ronciglione | 2 - 0 | Darida Michele |
| 2022-03-20 11:00:0020/03/22 | Maremmana 1934 — Valentano | 1 - 2 | Incotti |
| 2022-03-20 11:00:0020/03/22 | 1928 Vetralla — Allumiere | 2 - 1 | San Paolo |
| 2022-03-20 15:00:0020/03/22 | S.Lorenzo N. — Sporting Bagnoregio | 2 - 2 | Comunale |
| 2022-03-20 15:00:0020/03/22 | Tarquinia Calcio — Fortitudo Nepi Calcio | 1 - 1 | Bonelli Liviano |
| 2022-03-27 11:00:0027/03/22 | Atletico Cimina — Castel S.Elia L.Graziosi | 0 - 0 | Palozzi Rosato |
| 2022-03-27 11:00:0027/03/22 | Cura Calcio — Tarquinia Calcio | 0 - 3 | Nagni Luigi |
| 2022-03-27 11:00:0027/03/22 | Sporting Bagnoregio — Atletico Capranica | 0 - 3 | Pompei Alessandro |
| 2022-03-27 11:00:0027/03/22 | Fortitudo Nepi Calcio — Maremmana 1934 | 4 - 1 | Comunale |
| 2022-03-27 11:00:0027/03/22 | G.B. Bagnaia — Valentano | 1 - 1 | Buratti-Burocchi |
| 2022-03-27 15:00:0027/03/22 | Allumiere — S.Lorenzo N. | 3 - 1 | La Cavaccia |
| 2022-03-27 15:00:0027/03/22 | Vicus Ronciglione — 1928 Vetralla | 2 - 0 | Ginnasi Valerio C.Le |
| 2022-04-03 11:00:0003/04/22 | Castel S.Elia L.Graziosi — G.B. Bagnaia | 2 - 0 | Darida Michele |
| 2022-04-03 11:00:0003/04/22 | Maremmana 1934 — Cura Calcio | 2 - 0 | Incotti |
| 2022-04-03 11:00:0003/04/22 | Valentano — Fortitudo Nepi Calcio | 4 - 2 | Felceti |
| 2022-04-03 11:00:0003/04/22 | 1928 Vetralla — Atletico Cimina | 1 - 0 | San Paolo |
| 2022-04-03 11:00:0003/04/22 | Atletico Capranica — Allumiere | 5 - 0 | Morera Manlio |
| 2022-04-03 15:00:0003/04/22 | S.Lorenzo N. — Vicus Ronciglione | 4 - 0 | Comunale |
| 2022-04-03 15:00:0003/04/22 | Tarquinia Calcio — Sporting Bagnoregio | 3 - 2 | Bonelli Liviano |
| 2022-04-10 11:00:0010/04/22 | Atletico Cimina — S.Lorenzo N. | 1 - 1 | Palozzi Rosato |
| 2022-04-10 11:00:0010/04/22 | Castel S.Elia L.Graziosi — 1928 Vetralla | 2 - 1 | Darida Michele |
| 2022-04-10 11:00:0010/04/22 | Cura Calcio — Valentano | 1 - 1 | Nagni Luigi |
| 2022-04-10 11:00:0010/04/22 | G.B. Bagnaia — Fortitudo Nepi Calcio | 0 - 1 | Buratti-Burocchi |
| 2022-04-10 11:00:0010/04/22 | Sporting Bagnoregio — Maremmana 1934 | 2 - 0 | Pompei Alessandro |
| 2022-04-10 15:00:0010/04/22 | Allumiere — Tarquinia Calcio | 0 - 2 | La Cavaccia |
| 2022-04-10 15:00:0010/04/22 | Vicus Ronciglione — Atletico Capranica | 2 - 3 | Ginnasi Valerio C.Le |
| 2022-04-24 11:00:0024/04/22 | Atletico Capranica — Atletico Cimina | 4 - 1 | Morera Manlio |
| 2022-04-24 11:00:0024/04/22 | Maremmana 1934 — Allumiere | 2 - 1 | Incotti |
| 2022-04-24 11:00:0024/04/22 | Fortitudo Nepi Calcio — Cura Calcio | 4 - 1 | Comunale |
| 2022-04-24 11:00:0024/04/22 | Valentano — Sporting Bagnoregio | 3 - 0 | Felceti |
| 2022-04-24 11:00:0024/04/22 | 1928 Vetralla — G.B. Bagnaia | 1 - 0 | San Paolo |
| 2022-04-24 15:00:0024/04/22 | S.Lorenzo N. — Castel S.Elia L.Graziosi | 2 - 0 | Comunale |
| 2022-04-24 15:00:0024/04/22 | Tarquinia Calcio — Vicus Ronciglione | 3 - 0 | Bonelli Liviano |
| 2022-05-01 11:00:0001/05/22 | Sporting Bagnoregio — Fortitudo Nepi Calcio | 0 - 1 | Pompei Alessandro |
| 2022-05-01 11:00:0001/05/22 | 1928 Vetralla — S.Lorenzo N. | 2 - 1 | San Paolo |
| 2022-05-01 11:00:0001/05/22 | G.B. Bagnaia — Cura Calcio | 1 - 0 | Buratti-Burocchi |
| 2022-05-01 11:00:0001/05/22 | Atletico Cimina — Tarquinia Calcio | 0 - 2 | Palozzi Rosato |
| 2022-05-01 11:00:0001/05/22 | Castel S.Elia L.Graziosi — Atletico Capranica | 1 - 1 | Darida Michele |
| 2022-05-01 15:00:0001/05/22 | Vicus Ronciglione — Maremmana 1934 | 0 - 0 | Ginnasi Valerio C.Le |
| 2022-05-01 15:00:0001/05/22 | Allumiere — Valentano | 1 - 1 | La Cavaccia |
| 2022-05-08 11:00:0008/05/22 | Atletico Capranica — 1928 Vetralla | 3 - 1 | Morera Manlio |
| 2022-05-08 11:00:0008/05/22 | Cura Calcio — Sporting Bagnoregio | 2 - 2 | Nagni Luigi |
| 2022-05-08 11:00:0008/05/22 | Fortitudo Nepi Calcio — Allumiere | 2 - 0 | Comunale |
| 2022-05-08 11:00:0008/05/22 | Valentano — Vicus Ronciglione | 2 - 0 | Felceti |
| 2022-05-08 11:00:0008/05/22 | Maremmana 1934 — Atletico Cimina | 2 - 1 | Incotti |
| 2022-05-08 16:00:0008/05/22 | Tarquinia Calcio — Castel S.Elia L.Graziosi | 6 - 1 | Bonelli Liviano |
| 2022-05-08 16:00:0008/05/22 | S.Lorenzo N. — G.B. Bagnaia | 2 - 1 | Comunale |
| 2022-05-15 11:00:0015/05/22 | Atletico Cimina — Valentano | 1 - 3 | Palozzi Rosato |
| 2022-05-15 11:00:0015/05/22 | Castel S.Elia L.Graziosi — Maremmana 1934 | 3 - 0 | Darida Michele |
| 2022-05-15 11:00:0015/05/22 | G.B. Bagnaia — Sporting Bagnoregio | 0 - 3 | Buratti-Burocchi |
| 2022-05-15 11:00:0015/05/22 | 1928 Vetralla — Tarquinia Calcio | 1 - 2 | San Paolo |
| 2022-05-15 16:00:0015/05/22 | Allumiere — Cura Calcio | 1 - 0 | La Cavaccia |
| 2022-05-15 16:00:0015/05/22 | Vicus Ronciglione — Fortitudo Nepi Calcio | 2 - 1 | Ginnasi Valerio C.Le |
| 2022-05-15 16:00:0015/05/22 | S.Lorenzo N. — Atletico Capranica | 2 - 3 | Comunale |
| 2022-05-22 11:00:0022/05/22 | Cura Calcio — Vicus Ronciglione | 1 - 1 | Nagni Luigi |
| 2022-05-22 11:00:0022/05/22 | Fortitudo Nepi Calcio — Atletico Cimina | 4 - 3 | Comunale |
| 2022-05-22 11:00:0022/05/22 | Maremmana 1934 — 1928 Vetralla | 0 - 2 | Incotti |
| 2022-05-22 11:00:0022/05/22 | Valentano — Castel S.Elia L.Graziosi | 4 - 3 | Felceti |
| 2022-05-22 11:00:0022/05/22 | G.B. Bagnaia — Atletico Capranica | 1 - 1 | Buratti-Burocchi |
| 2022-05-22 11:00:0022/05/22 | Sporting Bagnoregio — Allumiere | 3 - 1 | Pompei Alessandro |
| 2022-05-22 16:00:0022/05/22 | Tarquinia Calcio — S.Lorenzo N. | 1 - 2 | Bonelli Liviano |
| 2022-05-29 11:00:0029/05/22 | 1928 Vetralla — Valentano | 0 - 0 | San Paolo |
| 2022-05-29 11:00:0029/05/22 | Atletico Capranica — Tarquinia Calcio | 3 - 0 | Morera Manlio |
| 2022-05-29 11:00:0029/05/22 | Castel S.Elia L.Graziosi — Fortitudo Nepi Calcio | 1 - 0 | Darida Michele |
| 2022-05-29 11:00:0029/05/22 | Atletico Cimina — Cura Calcio | 2 - 4 | Palozzi Rosato |
| 2022-05-29 16:30:0029/05/22 | Vicus Ronciglione — Sporting Bagnoregio | 3 - 3 | Ginnasi Valerio C.Le |
| 2022-05-29 16:30:0029/05/22 | S.Lorenzo N. — Maremmana 1934 | 3 - 0 | Comunale |
| 2022-05-29 16:30:0029/05/22 | Allumiere — G.B. Bagnaia | 0 - 0 | La Cavaccia |
