| 2021-10-03 11:00:0003/10/21 |   Alatri Calcio — Roccasecca T.S.T. | 1 - 6 | Fraiegari Gianni |
| 2021-10-03 11:00:0003/10/21 |   Ceccano Calcio 1920 — Virtus Faiti | 1 - 0 | Popolla Dante |
| 2021-10-03 11:00:0003/10/21 |   Latina Borghi Riuniti — Anitrella | 2 - 0 | Zonzin Oscar |
| 2021-10-03 11:00:0003/10/21 |   Nuovo Cos Latina — Sport Virtus Guarcino | 2 - 0 | Borgo Piave |
| 2021-10-03 15:00:0003/10/21 |   I.Lirina Academy Calcio — F.C. Montenero | 1 - 1 | Nazareth |
| 2021-10-03 15:30:0003/10/21 |   Atletico Pontinia — Citta di Lenola | 1 - 0 | Caporuscio Riccardo |
| 2021-10-03 15:30:0003/10/21 |   Monte San Biagio — Hermada | 4 - 1 | Comunale |
| 2021-10-03 15:30:0003/10/21 |   Real Cassino Colosseo — Polisportiva Tecchiena | 1 - 1 | Comunale |
| 2021-10-10 11:00:0010/10/21 | F.C. Montenero — Ceccano Calcio 1920 | 0 - 2 | San Francesco |
| 2021-10-10 11:00:0010/10/21 | Hermada — Real Cassino Colosseo | 3 - 2 | Stadio Della Vittoria |
| 2021-10-10 11:00:0010/10/21 | Polisportiva Tecchiena — Latina Borghi Riuniti | 1 - 0 | Tecchiena Castello |
| 2021-10-10 11:00:0010/10/21 | Virtus Faiti — Nuovo Cos Latina | 1 - 4 | Comunale |
| 2021-10-10 15:30:0010/10/21 | Anitrella — Alatri Calcio | 1 - 0 | Liri |
| 2021-10-10 15:30:0010/10/21 | Citta di Lenola — I.Lirina Academy Calcio | 1 - 1 | Borsellino Falcone&Scorta |
| 2021-10-10 15:30:0010/10/21 | Roccasecca T.S.T. — Atletico Pontinia | 1 - 0 | Battista Lino |
| 2021-10-10 15:30:0010/10/21 | Sport Virtus Guarcino — Monte San Biagio | 0 - 2 | Sant'andrea |
| 2021-10-17 11:00:0017/10/21 | Ceccano Calcio 1920 — Citta di Lenola | 2 - 0 | Popolla Dante |
| 2021-10-17 11:00:0017/10/21 | Latina Borghi Riuniti — Hermada | 2 - 0 | Zonzin Oscar |
| 2021-10-17 11:00:0017/10/21 | Nuovo Cos Latina — F.C. Montenero | 3 - 1 | Borgo Piave |
| 2021-10-17 11:00:0017/10/21 | Polisportiva Tecchiena — Anitrella | 2 - 1 | Tecchiena Castello |
| 2021-10-17 15:00:0017/10/21 | I.Lirina Academy Calcio — Roccasecca T.S.T. | 1 - 1 | Nazareth |
| 2021-10-17 15:30:0017/10/21 | Atletico Pontinia — Alatri Calcio | 5 - 3 | Caporuscio Riccardo |
| 2021-10-17 15:30:0017/10/21 | Monte San Biagio — Virtus Faiti | 7 - 0 | Comunale |
| 2021-10-17 15:30:0017/10/21 | Real Cassino Colosseo — Sport Virtus Guarcino | 7 - 2 | Comunale |
| 2021-10-24 11:00:0024/10/21 | Alatri Calcio — I.Lirina Academy Calcio | 4 - 0 | Fraiegari Gianni |
| 2021-10-24 11:00:0024/10/21 | F.C. Montenero — Monte San Biagio | 0 - 1 | San Francesco |
| 2021-10-24 11:00:0024/10/21 | Hermada — Polisportiva Tecchiena | 1 - 1 | Stadio Della Vittoria |
| 2021-10-24 11:00:0024/10/21 | Virtus Faiti — Real Cassino Colosseo | 2 - 4 | Comunale |
| 2021-10-24 15:30:0024/10/21 | Anitrella — Atletico Pontinia | 0 - 1 | Liri |
| 2021-10-24 15:30:0024/10/21 | Citta di Lenola — Nuovo Cos Latina | 1 - 1 | Borsellino Falcone&Scorta |
| 2021-10-24 15:30:0024/10/21 | Roccasecca T.S.T. — Ceccano Calcio 1920 | 1 - 1 | Battista Lino |
| 2021-10-24 15:30:0024/10/21 | Sport Virtus Guarcino — Latina Borghi Riuniti | 1 - 0 | Sant'andrea |
| 2021-11-01 11:00:0001/11/21 | Ceccano Calcio 1920 — Alatri Calcio | 2 - 1 | Popolla Dante |
| 2021-11-01 11:00:0001/11/21 | Hermada — Anitrella | 1 - 2 | Stadio Della Vittoria |
| 2021-11-01 11:00:0001/11/21 | Latina Borghi Riuniti — Virtus Faiti | 2 - 1 | Zonzin Oscar |
| 2021-11-01 11:00:0001/11/21 | Nuovo Cos Latina — Roccasecca T.S.T. | 0 - 0 | Borgo Piave |
| 2021-11-01 11:00:0001/11/21 | Polisportiva Tecchiena — Sport Virtus Guarcino | 2 - 2 | Tecchiena Castello |
| 2021-11-01 14:30:0001/11/21 | Monte San Biagio — Citta di Lenola | 4 - 1 | Comunale |
| 2021-11-01 14:30:0001/11/21 | Real Cassino Colosseo — F.C. Montenero | 1 - 1 | Comunale |
| 2021-11-01 15:00:0001/11/21 | I.Lirina Academy Calcio — Atletico Pontinia | 0 - 0 | Nazareth |
| 2021-11-07 11:00:0007/11/21 | Alatri Calcio — Nuovo Cos Latina | 2 - 4 | Fraiegari Gianni |
| 2021-11-07 11:00:0007/11/21 | F.C. Montenero — Latina Borghi Riuniti | 0 - 3 | San Francesco |
| 2021-11-07 11:00:0007/11/21 | Virtus Faiti — Polisportiva Tecchiena | 1 - 0 | Comunale |
| 2021-11-07 14:30:0007/11/21 | Anitrella — I.Lirina Academy Calcio | 1 - 0 | Liri |
| 2021-11-07 14:30:0007/11/21 | Atletico Pontinia — Ceccano Calcio 1920 | 3 - 1 | Caporuscio Riccardo |
| 2021-11-07 14:30:0007/11/21 | Citta di Lenola — Real Cassino Colosseo | 0 - 2 | Borsellino Falcone&Scorta |
| 2021-11-07 14:30:0007/11/21 | Roccasecca T.S.T. — Monte San Biagio | 1 - 2 | Battista Lino |
| 2021-11-07 14:30:0007/11/21 | Sport Virtus Guarcino — Hermada | 2 - 0 | Sant'andrea |
| 2021-11-14 11:00:0014/11/21 | Ceccano Calcio 1920 — I.Lirina Academy Calcio | 3 - 0 | Popolla Dante |
| 2021-11-14 11:00:0014/11/21 | Hermada — Virtus Faiti | 3 - 1 | Stadio Della Vittoria |
| 2021-11-14 11:00:0014/11/21 | Latina Borghi Riuniti — Citta di Lenola | 2 - 0 | Zonzin Oscar |
| 2021-11-14 11:00:0014/11/21 | Nuovo Cos Latina — Atletico Pontinia | 0 - 1 | Borgo Piave |
| 2021-11-14 11:00:0014/11/21 | Polisportiva Tecchiena — F.C. Montenero | 2 - 0 | Tecchiena Castello |
| 2021-11-14 14:30:0014/11/21 | Monte San Biagio — Alatri Calcio | 2 - 2 | Comunale |
| 2021-11-14 14:30:0014/11/21 | Real Cassino Colosseo — Roccasecca T.S.T. | 0 - 1 | Comunale |
| 2021-11-14 14:30:0014/11/21 | Sport Virtus Guarcino — Anitrella | 2 - 3 | Sant'andrea |
| 2021-11-21 11:00:0021/11/21 | Alatri Calcio — Real Cassino Colosseo | 2 - 0 | Fraiegari Gianni |
| 2021-11-21 11:00:0021/11/21 | F.C. Montenero — Hermada | 1 - 1 | San Francesco |
| 2021-11-21 11:00:0021/11/21 | Virtus Faiti — Sport Virtus Guarcino | 2 - 3 | Comunale |
| 2021-11-21 14:30:0021/11/21 | Anitrella — Ceccano Calcio 1920 | 1 - 3 | Liri |
| 2021-11-21 14:30:0021/11/21 | Atletico Pontinia — Monte San Biagio | 0 - 1 | Caporuscio Riccardo |
| 2021-11-21 14:30:0021/11/21 | Citta di Lenola — Polisportiva Tecchiena | 0 - 1 | Borsellino Falcone&Scorta |
| 2021-11-21 14:30:0021/11/21 | Roccasecca T.S.T. — Latina Borghi Riuniti | 1 - 1 | Battista Lino |
| 2021-11-21 15:00:0021/11/21 | I.Lirina Academy Calcio — Nuovo Cos Latina | 1 - 1 | Nazareth |
| 2021-11-28 11:00:0028/11/21 | Hermada — Citta di Lenola | 2 - 3 | Stadio Della Vittoria |
| 2021-11-28 11:00:0028/11/21 | Latina Borghi Riuniti — Alatri Calcio | 3 - 0 | Zonzin Oscar |
| 2021-11-28 11:00:0028/11/21 | Nuovo Cos Latina — Ceccano Calcio 1920 | 2 - 1 | Borgo Piave |
| 2021-11-28 11:00:0028/11/21 | Polisportiva Tecchiena — Roccasecca T.S.T. | 3 - 2 | Tecchiena Castello |
| 2021-11-28 11:00:0028/11/21 | Virtus Faiti — Anitrella | 2 - 0 | Comunale |
| 2021-11-28 14:30:0028/11/21 | Monte San Biagio — I.Lirina Academy Calcio | 7 - 0 | Comunale |
| 2021-11-28 14:30:0028/11/21 | Real Cassino Colosseo — Atletico Pontinia | 0 - 1 | Comunale |
| 2021-11-28 14:30:0028/11/21 | Sport Virtus Guarcino — F.C. Montenero | 2 - 0 | Sant'andrea |
| 2021-12-08 11:00:0008/12/21 | Alatri Calcio — Polisportiva Tecchiena | 2 - 2 | Fraiegari Gianni |
| 2021-12-08 11:00:0008/12/21 | Ceccano Calcio 1920 — Monte San Biagio | 0 - 1 | Popolla Dante |
| 2021-12-08 11:00:0008/12/21 | F.C. Montenero — Virtus Faiti | 4 - 0 | San Francesco |
| 2021-12-08 14:30:0008/12/21 | Anitrella — Nuovo Cos Latina | 0 - 1 | Liri |
| 2021-12-08 14:30:0008/12/21 | Atletico Pontinia — Latina Borghi Riuniti | 2 - 2 | Caporuscio Riccardo |
| 2021-12-08 14:30:0008/12/21 | Citta di Lenola — Sport Virtus Guarcino | 3 - 1 | Borsellino Falcone&Scorta |
| 2021-12-08 14:30:0008/12/21 | Roccasecca T.S.T. — Hermada | 2 - 1 | Battista Lino |
| 2021-12-08 15:00:0008/12/21 | I.Lirina Academy Calcio — Real Cassino Colosseo | 1 - 3 | Nazareth |
| 2021-12-12 11:00:0012/12/21 | F.C. Montenero — Anitrella | 2 - 2 | San Francesco |
| 2021-12-12 11:00:0012/12/21 | Hermada — Alatri Calcio | 6 - 2 | Stadio Della Vittoria |
| 2021-12-12 11:00:0012/12/21 | Polisportiva Tecchiena — Atletico Pontinia | 1 - 0 | Tecchiena Castello |
| 2021-12-12 11:00:0012/12/21 | Latina Borghi Riuniti — I.Lirina Academy Calcio | 2 - 0 | Zonzin Oscar |
| 2021-12-12 11:00:0012/12/21 | Virtus Faiti — Citta di Lenola | 0 - 1 | Comunale |
| 2021-12-12 14:30:0012/12/21 | Monte San Biagio — Nuovo Cos Latina | 0 - 0 | Comunale |
| 2021-12-12 14:30:0012/12/21 | Real Cassino Colosseo — Ceccano Calcio 1920 | 0 - 3 | Comunale |
| 2021-12-12 14:30:0012/12/21 | Sport Virtus Guarcino — Roccasecca T.S.T. | 1 - 1 | Sant'andrea |
| 2021-12-19 11:00:0019/12/21 | Alatri Calcio — Sport Virtus Guarcino | 4 - 2 | Fraiegari Gianni |
| 2021-12-19 11:00:0019/12/21 | Ceccano Calcio 1920 — Latina Borghi Riuniti | 1 - 0 | Popolla Dante |
| 2021-12-19 11:00:0019/12/21 | Nuovo Cos Latina — Real Cassino Colosseo | 1 - 1 | Borgo Piave |
| 2021-12-19 14:30:0019/12/21 | Anitrella — Monte San Biagio | 1 - 1 | Liri |
| 2021-12-19 14:30:0019/12/21 | Atletico Pontinia — Hermada | 4 - 3 | Caporuscio Riccardo |
| 2021-12-19 14:30:0019/12/21 | Citta di Lenola — F.C. Montenero | 1 - 1 | Borsellino Falcone&Scorta |
| 2021-12-19 14:30:0019/12/21 | Roccasecca T.S.T. — Virtus Faiti | 2 - 0 | Battista Lino |
| 2021-12-19 15:00:0019/12/21 | I.Lirina Academy Calcio — Polisportiva Tecchiena | 1 - 0 | Nazareth |
| 2021-12-23 11:00:0023/12/21 | Hermada — I.Lirina Academy Calcio | 2 - 1 | Stadio Della Vittoria |
| 2021-12-23 11:00:0023/12/21 | F.C. Montenero — Roccasecca T.S.T. | 2 - 1 | San Francesco |
| 2021-12-23 11:00:0023/12/21 | Latina Borghi Riuniti — Nuovo Cos Latina | 0 - 2 | Zonzin Oscar |
| 2021-12-23 11:00:0023/12/21 | Polisportiva Tecchiena — Ceccano Calcio 1920 | 2 - 1 | Tecchiena Castello |
| 2021-12-23 11:00:0023/12/21 | Virtus Faiti — Alatri Calcio | 7 - 3 | Comunale |
| 2021-12-23 14:30:0023/12/21 | Citta di Lenola — Anitrella | 4 - 0 | Borsellino Falcone&Scorta |
| 2021-12-23 14:30:0023/12/21 | Real Cassino Colosseo — Monte San Biagio | 0 - 0 | Comunale |
| 2021-12-23 14:30:0023/12/21 | Sport Virtus Guarcino — Atletico Pontinia | 1 - 4 | Sant'andrea |
| 2022-01-06 11:00:0006/01/22 | Alatri Calcio — F.C. Montenero | 1 - 6 | Fraiegari Gianni |
| 2022-01-06 11:00:0006/01/22 | Ceccano Calcio 1920 — Hermada | 2 - 1 | Popolla Dante |
| 2022-01-06 11:00:0006/01/22 | Nuovo Cos Latina — Polisportiva Tecchiena | 3 - 0 | Borgo Piave |
| 2022-01-06 14:30:0006/01/22 | Atletico Pontinia — Virtus Faiti | 2 - 0 | Caporuscio Riccardo |
| 2022-01-06 14:30:0006/01/22 | Monte San Biagio — Latina Borghi Riuniti | 3 - 0 | Comunale |
| 2022-01-06 14:30:0006/01/22 | Real Cassino Colosseo — Anitrella | 0 - 0 | Comunale |
| 2022-01-06 14:30:0006/01/22 | Roccasecca T.S.T. — Citta di Lenola | 1 - 0 | Battista Lino |
| 2022-01-06 15:00:0006/01/22 | I.Lirina Academy Calcio — Sport Virtus Guarcino | 2 - 3 | Nazareth |
| 2022-01-09 11:00:0009/01/22 | F.C. Montenero — Atletico Pontinia | 0 - 0 | San Francesco |
| 2022-01-09 11:00:0009/01/22 | Hermada — Nuovo Cos Latina | 0 - 1 | Stadio Della Vittoria |
| 2022-01-09 11:00:0009/01/22 | Latina Borghi Riuniti — Real Cassino Colosseo | 0 - 1 | Zonzin Oscar |
| 2022-01-09 11:00:0009/01/22 | Virtus Faiti — I.Lirina Academy Calcio | 2 - 2 | Comunale |
| 2022-01-09 11:00:0009/01/22 | Polisportiva Tecchiena — Monte San Biagio | 0 - 1 | Tecchiena Castello |
| 2022-01-09 14:30:0009/01/22 | Anitrella — Roccasecca T.S.T. | 2 - 2 | Liri |
| 2022-01-09 14:30:0009/01/22 | Citta di Lenola — Alatri Calcio | 3 - 0 | Borsellino Falcone&Scorta |
| 2022-01-09 14:30:0009/01/22 | Sport Virtus Guarcino — Ceccano Calcio 1920 | 1 - 1 | Sant'andrea |
| 2022-02-13 11:00:0013/02/22 | Polisportiva Tecchiena — Real Cassino Colosseo | 1 - 0 | Tecchiena Castello |
| 2022-02-13 11:00:0013/02/22 | Sport Virtus Guarcino — Nuovo Cos Latina | 1 - 2 | Sant'andrea |
| 2022-02-13 11:00:0013/02/22 | Hermada — Monte San Biagio | 1 - 3 | Stadio Della Vittoria |
| 2022-02-13 11:00:0013/02/22 | Football Club Montenero — I.Lirinia Academy Calcio | 3 - 2 | Ballarin Aldo |
| 2022-02-13 14:30:0013/02/22 | Anitrella — Latina Borghi Riuniti | 1 - 1 | Liri |
| 2022-02-13 14:30:0013/02/22 | Citta di Lenola — Atletico Pontinia | 2 - 1 | Borsellino Falcone&Scorta |
| 2022-02-13 14:30:0013/02/22 | Roccasecca T.S.T. — Alatri Calcio | 3 - 0 | Battista Lino |
| 2022-02-13 14:30:0013/02/22 | Virtus Faiti — Ceccano Calcio 1920 | 0 - 2 | Comunale |
| 2022-02-20 11:00:0020/02/22 | Latina Borghi Riuniti — Polisportiva Tecchiena | 1 - 0 | Zonzin Oscar |
| 2022-02-20 11:00:0020/02/22 | Alatri Calcio — Anitrella | 1 - 2 | Fraiegari Gianni |
| 2022-02-20 11:00:0020/02/22 | Atletico Pontinia — Roccasecca T.S.T. | 2 - 1 | Caporuscio Riccardo A |
| 2022-02-20 14:30:0020/02/22 | Monte San Biagio — Sport Virtus Guarcino | 1 - 2 | Comunale |
| 2022-02-20 14:30:0020/02/22 | Real Cassino Colosseo — Hermada | 2 - 1 | Comunale |
| 2022-02-20 15:00:0020/02/22 | I.Lirinia Academy Calcio — Citta di Lenola | 1 - 0 | Nazareth |
| 2022-02-20 15:00:0020/02/22 | Ceccano Calcio 1920 — Football Club Montenero | 4 - 1 | Popolla Dante |
| 2022-02-20 15:00:0020/02/22 | Nuovo Cos Latina — Virtus Faiti | 1 - 0 | Ceccarelli Ivano |
| 2022-02-27 11:00:0027/02/22 | Football Club Montenero — Nuovo Cos Latina | 1 - 3 | Ballarin Aldo |
| 2022-02-27 11:00:0027/02/22 | Sport Virtus Guarcino — Real Cassino Colosseo | 4 - 1 | Sant'andrea |
| 2022-02-27 11:00:0027/02/22 | Hermada — Latina Borghi Riuniti | 1 - 4 | Stadio Della Vittoria |
| 2022-02-27 11:00:0027/02/22 | Alatri Calcio — Atletico Pontinia | 0 - 3 | Fraiegari Gianni |
| 2022-02-27 15:00:0027/02/22 | Citta di Lenola — Ceccano Calcio 1920 | Rinv | Borsellino Falcone&Scorta |
| 2022-02-27 15:00:0027/02/22 | Anitrella — Polisportiva Tecchiena | 0 - 0 | Liri |
| 2022-02-27 15:00:0027/02/22 | Virtus Faiti — Monte San Biagio | 1 - 2 | Comunale |
| 2022-02-27 15:00:0027/02/22 | Roccasecca T.S.T. — I.Lirinia Academy Calcio | 1 - 1 | Battista Lino |
| 2022-03-06 11:00:0006/03/22 | Latina Borghi Riuniti — Sport Virtus Guarcino | 3 - 2 | Zonzin Oscar |
| 2022-03-06 11:00:0006/03/22 | Polisportiva Tecchiena — Hermada | 3 - 1 | Tecchiena Castello |
| 2022-03-06 15:00:0006/03/22 | Monte San Biagio — Football Club Montenero | 5 - 1 | Comunale |
| 2022-03-06 15:00:0006/03/22 | I.Lirinia Academy Calcio — Alatri Calcio | 4 - 1 | Nazareth |
| 2022-03-06 15:00:0006/03/22 | Atletico Pontinia — Anitrella | 1 - 0 | Caporuscio Riccardo A |
| 2022-03-06 15:00:0006/03/22 | Ceccano Calcio 1920 — Roccasecca T.S.T. | 3 - 0 | Popolla Dante |
| 2022-03-06 15:00:0006/03/22 | Real Cassino Colosseo — Virtus Faiti | 4 - 0 | Comunale |
| 2022-03-06 15:00:0006/03/22 | Nuovo Cos Latina — Citta di Lenola | 2 - 0 | Ceccarelli Ivano |
| 2022-03-13 11:00:0013/03/22 | Football Club Montenero — Real Cassino Colosseo | 3 - 1 | Ballarin Aldo |
| 2022-03-13 11:00:0013/03/22 | Alatri Calcio — Ceccano Calcio 1920 | 0 - 5 | Fraiegari Gianni |
| 2022-03-13 11:00:0013/03/22 | Atletico Pontinia — I.Lirinia Academy Calcio | 3 - 0 | Caporuscio Riccardo A |
| 2022-03-13 11:00:0013/03/22 | Sport Virtus Guarcino — Polisportiva Tecchiena | 0 - 0 | Sant'andrea |
| 2022-03-13 15:00:0013/03/22 | Virtus Faiti — Latina Borghi Riuniti | 2 - 1 | Comunale |
| 2022-03-13 15:00:0013/03/22 | Roccasecca T.S.T. — Nuovo Cos Latina | 0 - 1 | Battista Lino |
| 2022-03-13 15:00:0013/03/22 | Anitrella — Hermada | 2 - 1 | Liri |
| 2022-03-13 15:00:0013/03/22 | Citta di Lenola — Monte San Biagio | 1 - 2 | Borsellino Falcone&Scorta |
| 2022-03-23 11:00:0023/03/22 | Hermada — Sport Virtus Guarcino | 2 - 2 | Stadio Della Vittoria |
| 2022-03-23 11:00:0023/03/22 | Polisportiva Tecchiena — Virtus Faiti | 1 - 0 | Tecchiena Castello |
| 2022-03-23 11:00:0023/03/22 | Latina Borghi Riuniti — Football Club Montenero | 0 - 0 | Zonzin Oscar |
| 2022-03-23 15:00:0023/03/22 | Ceccano Calcio 1920 — Atletico Pontinia | 2 - 1 | Popolla Dante |
| 2022-03-23 15:00:0023/03/22 | Monte San Biagio — Roccasecca T.S.T. | 5 - 0 | Comunale |
| 2022-03-23 15:00:0023/03/22 | Nuovo Cos Latina — Alatri Calcio | 5 - 2 | Ceccarelli Ivano |
| 2022-03-23 15:00:0023/03/22 | I.Lirinia Academy Calcio — Anitrella | 0 - 1 | Nazareth |
| 2022-03-23 15:00:0023/03/22 | Real Cassino Colosseo — Citta di Lenola | 1 - 1 | Comunale |
| 2022-03-27 11:00:0027/03/22 | Atletico Pontinia — Nuovo Cos Latina | 1 - 0 | Caporuscio Riccardo A |
| 2022-03-27 11:00:0027/03/22 | Football Club Montenero — Polisportiva Tecchiena | 0 - 0 | Ballarin Aldo |
| 2022-03-27 11:00:0027/03/22 | Alatri Calcio — Monte San Biagio | 1 - 7 | Fraiegari Gianni |
| 2022-03-27 15:00:0027/03/22 | Roccasecca T.S.T. — Real Cassino Colosseo | 1 - 0 | Battista Lino |
| 2022-03-27 15:00:0027/03/22 | Virtus Faiti — Hermada | 0 - 0 | Comunale |
| 2022-03-27 15:00:0027/03/22 | Citta di Lenola — Latina Borghi Riuniti | 1 - 3 | Borsellino Falcone&Scorta |
| 2022-03-27 15:00:0027/03/22 | I.Lirinia Academy Calcio — Ceccano Calcio 1920 | 0 - 3 | Nazareth |
| 2022-03-27 15:00:0027/03/22 | Anitrella — Sport Virtus Guarcino | 0 - 0 | Liri |
| 2022-04-03 11:00:0003/04/22 | Hermada — Football Club Montenero | 0 - 2 | Stadio Della Vittoria |
| 2022-04-03 11:00:0003/04/22 | Latina Borghi Riuniti — Roccasecca T.S.T. | 1 - 1 | Zonzin Oscar |
| 2022-04-03 11:00:0003/04/22 | Polisportiva Tecchiena — Citta di Lenola | 2 - 1 | Tecchiena Castello |
| 2022-04-03 11:00:0003/04/22 | Sport Virtus Guarcino — Virtus Faiti | 2 - 0 | Sant'andrea |
| 2022-04-03 15:00:0003/04/22 | Real Cassino Colosseo — Alatri Calcio | 7 - 1 | Comunale |
| 2022-04-03 15:00:0003/04/22 | Monte San Biagio — Atletico Pontinia | 2 - 0 | Comunale |
| 2022-04-03 15:00:0003/04/22 | Nuovo Cos Latina — I.Lirinia Academy Calcio | 6 - 0 | Ceccarelli Ivano |
| 2022-04-03 15:00:0003/04/22 | Ceccano Calcio 1920 — Anitrella | 2 - 0 | Popolla Dante |
| 2022-04-10 11:00:0010/04/22 | Atletico Pontinia — Real Cassino Colosseo | 1 - 2 | Caporuscio Riccardo A |
| 2022-04-10 11:00:0010/04/22 | Alatri Calcio — Latina Borghi Riuniti | 2 - 6 | Fraiegari Gianni |
| 2022-04-10 11:00:0010/04/22 | Football Club Montenero — Sport Virtus Guarcino | 2 - 3 | Ballarin Aldo |
| 2022-04-10 15:00:0010/04/22 | Ceccano Calcio 1920 — Nuovo Cos Latina | 1 - 3 | Popolla Dante |
| 2022-04-10 15:00:0010/04/22 | Citta di Lenola — Hermada | 3 - 3 | Borsellino Falcone&Scorta |
| 2022-04-10 15:00:0010/04/22 | Roccasecca T.S.T. — Polisportiva Tecchiena | 0 - 1 | Battista Lino |
| 2022-04-10 15:00:0010/04/22 | Anitrella — Virtus Faiti | 2 - 2 | Liri |
| 2022-04-10 15:00:0010/04/22 | I.Lirinia Academy Calcio — Monte San Biagio | 1 - 3 | Nazareth |
| 2022-04-24 11:00:0024/04/22 | Hermada — Roccasecca T.S.T. | 2 - 2 | Stadio Della Vittoria |
| 2022-04-24 11:00:0024/04/22 | Latina Borghi Riuniti — Atletico Pontinia | 0 - 2 | Zonzin Oscar |
| 2022-04-24 11:00:0024/04/22 | Sport Virtus Guarcino — Citta di Lenola | 3 - 1 | Sant'andrea |
| 2022-04-24 11:00:0024/04/22 | Polisportiva Tecchiena — Alatri Calcio | 3 - 0 | Tecchiena Castello |
| 2022-04-24 15:00:0024/04/22 | Monte San Biagio — Ceccano Calcio 1920 | 1 - 1 | Comunale |
| 2022-04-24 15:00:0024/04/22 | Real Cassino Colosseo — I.Lirinia Academy Calcio | 4 - 0 | Comunale |
| 2022-04-24 15:00:0024/04/22 | Virtus Faiti — Football Club Montenero | 0 - 1 | Comunale |
| 2022-04-24 15:00:0024/04/22 | Nuovo Cos Latina — Anitrella | 1 - 1 | Ceccarelli Ivano |
| 2022-05-01 11:00:0001/05/22 | Alatri Calcio — Hermada | 2 - 4 | Fraiegari Gianni |
| 2022-05-01 15:00:0001/05/22 | Citta di Lenola — Virtus Faiti | 2 - 0 | Borsellino Falcone&Scorta |
| 2022-05-01 15:00:0001/05/22 | Roccasecca T.S.T. — Sport Virtus Guarcino | 0 - 3 | Battista Lino |
| 2022-05-01 15:00:0001/05/22 | Nuovo Cos Latina — Monte San Biagio | 0 - 0 | Ceccarelli Ivano |
| 2022-05-01 15:00:0001/05/22 | Anitrella — Football Club Montenero | 1 - 1 | Liri |
| 2022-05-01 16:00:0001/05/22 | Atletico Pontinia — Polisportiva Tecchiena | 2 - 1 | Caporuscio Riccardo A |
| 2022-05-01 16:00:0001/05/22 | Ceccano Calcio 1920 — Real Cassino Colosseo | 4 - 2 | Popolla Dante |
| 2022-05-01 16:00:0001/05/22 | I.Lirinia Academy Calcio — Latina Borghi Riuniti | 0 - 2 | Nazareth |
| 2022-05-08 11:00:0008/05/22 | Football Club Montenero — Citta di Lenola | 2 - 0 | Ballarin Aldo |
| 2022-05-08 11:00:0008/05/22 | Hermada — Atletico Pontinia | 2 - 1 | Stadio Della Vittoria |
| 2022-05-08 11:00:0008/05/22 | Latina Borghi Riuniti — Ceccano Calcio 1920 | 1 - 1 | Zonzin Oscar |
| 2022-05-08 11:00:0008/05/22 | Polisportiva Tecchiena — I.Lirinia Academy Calcio | 3 - 0 | Tecchiena Castello |
| 2022-05-08 11:00:0008/05/22 | Sport Virtus Guarcino — Alatri Calcio | 6 - 2 | Sant'andrea |
| 2022-05-08 16:00:0008/05/22 | Virtus Faiti — Roccasecca T.S.T. | 0 - 2 | Comunale |
| 2022-05-08 16:00:0008/05/22 | Monte San Biagio — Anitrella | 1 - 0 | Comunale |
| 2022-05-08 16:00:0008/05/22 | Real Cassino Colosseo — Nuovo Cos Latina | 2 - 0 | Comunale |
| 2022-05-15 11:00:0015/05/22 | Alatri Calcio — Virtus Faiti | 6 - 3 | Fraiegari Gianni |
| 2022-05-15 11:00:0015/05/22 | Atletico Pontinia — Sport Virtus Guarcino | 1 - 1 | Caporuscio Riccardo A |
| 2022-05-15 15:00:0015/05/22 | Nuovo Cos Latina — Latina Borghi Riuniti | 0 - 0 | Ceccarelli Ivano |
| 2022-05-15 16:00:0015/05/22 | Monte San Biagio — Real Cassino Colosseo | 2 - 0 | Comunale |
| 2022-05-15 16:00:0015/05/22 | Roccasecca T.S.T. — Football Club Montenero | 0 - 0 | Battista Lino |
| 2022-05-15 16:00:0015/05/22 | Anitrella — Citta di Lenola | 0 - 0 | Liri |
| 2022-05-15 16:00:0015/05/22 | I.Lirinia Academy Calcio — Hermada | 0 - 1 | Nazareth |
| 2022-05-15 16:00:0015/05/22 | Ceccano Calcio 1920 — Polisportiva Tecchiena | 3 - 1 | Popolla Dante |
| 2022-05-22 11:00:0022/05/22 | Latina Borghi Riuniti — Monte San Biagio | 2 - 3 | Zonzin Oscar |
| 2022-05-22 11:00:0022/05/22 | Football Club Montenero — Alatri Calcio | 8 - 2 | Ballarin Aldo |
| 2022-05-22 11:00:0022/05/22 | Polisportiva Tecchiena — Nuovo Cos Latina | 0 - 1 | Tecchiena Castello |
| 2022-05-22 11:00:0022/05/22 | Hermada — Ceccano Calcio 1920 | 0 - 1 | Stadio Della Vittoria |
| 2022-05-22 11:00:0022/05/22 | Sport Virtus Guarcino — I.Lirinia Academy Calcio | 3 - 0 | Sant'andrea |
| 2022-05-22 16:00:0022/05/22 | Citta di Lenola — Roccasecca T.S.T. | 2 - 2 | Borsellino Falcone&Scorta |
| 2022-05-22 16:00:0022/05/22 | Anitrella — Real Cassino Colosseo | 2 - 1 | Liri |
| 2022-05-22 16:00:0022/05/22 | Virtus Faiti — Atletico Pontinia | 1 - 3 | Comunale |
| 2022-06-02 11:00:0002/06/22 | Roccasecca T.S.T. — Anitrella | 2 - 0 | Battista Lino |
| 2022-06-02 11:00:0002/06/22 | Real Cassino Colosseo — Latina Borghi Riuniti | 2 - 2 | Comunale |
| 2022-06-02 11:00:0002/06/22 | Nuovo Cos Latina — Hermada | 5 - 4 | Ceccarelli Ivano |
| 2022-06-02 11:00:0002/06/22 | Alatri Calcio — Citta di Lenola | 2 - 4 | Fraiegari Gianni |
| 2022-06-02 11:00:0002/06/22 | I.Lirinia Academy Calcio — Virtus Faiti | 2 - 1 | Nazareth |
| 2022-06-02 11:00:0002/06/22 | Atletico Pontinia — Football Club Montenero | 1 - 2 | Caporuscio Riccardo A |
| 2022-06-02 11:00:0002/06/22 | Ceccano Calcio 1920 — Sport Virtus Guarcino | 5 - 3 | Popolla Dante |
| 2022-06-02 16:30:0002/06/22 | Monte San Biagio — Polisportiva Tecchiena | 2 - 1 | Comunale |
Monte San Biagio
Nuovo Cos Latina
Ceccano Calcio 1920
Atletico Pontinia
Polisportiva Tecchiena
Latina Borghi Riuniti
Sport Virtus Guarcino
Roccasecca T.S.T.
Real Cassino Col.
Anitrella
Citta di Lenola
Hermada
F.C. Montenero
Virtus Faiti
Alatri Calcio
I.Lirina Academy Calcio
